Technische Universität, Dresden | Germany
My lab works on chromatin and the regulation of gene expression in mammalian development with emphasis on trithorax-Group action. Consequently we identified the PHD finger and the first histone 3 lysine 4 methyltransferase complex, as well as the current focus on the epigenome from germ cell to adult. To help unravel the epigenome, we developed a variety of methods, including ligand activated conditional mutagenesis and recombineering.
Keywords: Epigenetics / histone modifications / chromatin / genetic engineering / mouse models