MRC LMB, Cambridge | United Kingdom
In collaboration with Kiyoshi Nagai, my current research uses biochemical, genetic and structural methods to understand the structure and functions of the U5 snRNP protein Prp8: the largest and most conserved spliceosomal protein. Prp8 forms the active site cavity of the spliceosome and interacts extensively with crucial sequences in the spliceosome's catalytic RNA core.
Keywords: Splicing of mRNA precursors / structure & function of spliceosomes / Prp8 protein / U5 snRNP
Subject area(s): RNA