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EMBO Member

Carl-Henrik Heldin

Ludwig Institute for Cancer Research, Uppsala | Sweden

EMBO 1989 | MemC 05–08 | Council 08–10 | Council 15–15 | Council 16–17

Mechanism of action of growth regulatory factors

My research focuses on the mechanisms whereby growth factors, in particular PDGF and TGF-beta, activate their receptors and control cell growth, migration, apoptosis and differentiation, and how perturbations of signaling pathways promote tumor progression. An aim is to explore the usefulness of signal transduction inhibitors for tumor treatment.

Keywords: Molecular mechanisms of cellular growth control / structural & functional characterization of growth regulatory factors / signal transduction

Subject area(s): Molecular Medicine | Signal Transduction

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