Institut Pasteur, Paris | France
We study protein trafficking and disease. We found that in polarized cells GPI-anchored protein sorting at the Golgi controls their organization at the apical membrane and function. We demonstrated that trafficking affects prion pathological conversion and showed that Tunneling Nanotubes allow prion intercellular dissemination. We propose that TNTs are involved in the spreading of different prion-like proteins in neurodegenerative diseases.
Keywords: Apical sorting / GPI-proteins / prion spreading / tunneling nanotubes / prion-like diseases / membrane dynamics / imaging