EMBO Member

Keith Gull

University of Oxford | United Kingdom

EMBO 2010

Trypanosome cytoskeleton and antigenic variation

My research focuses on how the microtubule cytoskeleton of African trypanosomes is built and contributes to shape, form and motility of these parasites. In addition I am interested in the molecular and cell biological mechanisms controlling antigenic variation in African trypanosomes. We have a particular focus on the mechanisms underpinning monoallelic expression of the many variable antigen genes.

Keywords: Trypanosome / cytoskeleton / flagella / cilia / microtubule / antigenic variation / Pol1 / nuclear bodies

Subject area(s): Cell Cycle | Cell & Tissue Architecture | Microbiology, Virology & Pathogens