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EMBO Young Investigator

Kikue Tachibana-Konwalski

IMBA, Vienna | Austria

YIP 2017

Chromatin reprogramming to totipotency in mammals

Our research focuses on how chromatin is epigenetically reprogrammed to a totipotent state in vivo. We use mechanistic cell biology, spatial genome organization and genetics to study the conversion of female germ cells by fertilization into single-cell embryos, the oocyte-to-zygote transition. Our insights into meiotic chromosome segregation in oocytes and zygotic reprogramming are relevant for maternal age-related egg aneuploidy and infertility.

Keywords: Totipotency / chromatin / reprogramming / cell cycle / meiosis / ageing / chromosome dynamics

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Cell Cycle

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