EMBO Young Investigator
Our goal is to understand how telomeres control cell proliferation potential. We focus on the mechanisms of telomere replication and shortening and investigate how telomeres regulate cell cycle progression, in particular when they become critically short and trigger replicative senescence. We combine yeast genetics with molecular biology, biophysics and mathematical modelling to manipulate and track single telomeres in single cell lineages.
Keywords: Telomere / telomerase / replicative senescence / DNA replication / DNA repair