EMBO Member

Marileen Dogterom

Delft University of Technology | Netherlands

EMBO 2013

Reconstitution of complex cytoskeletal systems

My group is interested in understanding the principles by which the cytoskeleton organises the interior of cells. We focus in particular on the role of microtubule dynamics and force generation in mitotic spindle formation, polarity establishment, and cross-talk between microtubules and actin filaments. We reconstitute increasingly complex cytoskeletal systems in artificial confinement, made using microfabrication and microfluidics techniques.

Keywords: Cell biophysics / cytoskeletal organization / microtubule force generation / in vitro reconstitution / modelling / microfluidics / synthetic cells

Subject area(s): Cell & Tissue Architecture | Membranes & Transport | Structural Biology & Biophysics