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EMBO Member

Mary O'Connell

Masaryk University, Brno | Czech Republic

EMBO 2017

Elucidating the biological function of ADARs

My group is interested in determining the biological role of ADARs: the RNA editing enzymes that convert adenosine to inosine in dsRNA. ADAR1 is essential for innate immunity; however questions remain on how this occurs. ADAR2 is important for correct functioning of the nervous system. We also use Drosophila as a model system; mutants of the single Adar gene are barely viable and also have an innate immune phenotype which is highly significant.

Keywords: RNA biology / RNA editing / RNA modification / adenosine deaminases acting on RNA (ADARs) / innate immunity / Drosophila / dsRNA

Subject area(s): RNA | Proteins & Biochemistry | Immunology

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