Friedrich Miescher Institute, Basel | Switzerland
Our goal is to understand the fundamental mechanisms controlling normal and neoplastic breast cell heterogeneity. At the molecular, cellular, and whole organism levels, we assess mechanisms that influence normal and neoplastic breast stem cells, metastasis, and resistance to therapies. We explore both cell autonomous and non-cell autonomous mechanisms, use systems medicine quantitative methods, screens, and hypothesis-driven approaches.
Keywords: Mammary gland biology / breast cancer / stem cells / metastasis / signaling pathways / cancer therapy / resistance