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EMBO Associate Member

Ronald M. Evans

Salk Institute, La Jolla | United States

EMBO 2006

Nuclear receptors and hormone signaling

The discovery of steroid receptors and, subsequently, the family of orphan nuclear receptors provides a molecular approach to study metabolic regulation by fat-soluble hormones, vitamins, and dietary lipids. I am interested in the origins of physiology and the molecular genetics of muscle performance, metabolic disease, inflammation (including atherosclerosis and diabetes), and cancer and using this information to devise small-molecule therapy.

Keywords: Nuclear hormone receptors / metabolic disease / transcriptional control / steroid hormones / molecular medicine / chromatin

Subject area(s): Chromatin & Transcription | Molecular Medicine | Signal Transduction

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