University, Dundee | United Kingdom
My laboratory established conjugation with the Small Ubiquitin-like Modifier (SUMO) as an important regulatory mechanism in eukaryotes. We demonstrated that poly-SUMO chains could act as recognition sites for the ubiquitin ligase Rnf4. This targets Promyelocytic Leukaemia (PML) protein for arsenic-induced, ubiquitin-mediated proteolysis and establishes the molecular basis of arsenic therapy in the treatment of leukaemia.
Keywords: SUMO / ubiquitin / E3 ligase / SUMO protease / RNF4