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EMBO Member

Sjors H.W. Scheres

MRC LMB, Cambridge | United Kingdom

EMBO 2017

Development of cryoEM methods

In my group we develop new methods for cryoEM structure determination. I introduced a Bayesian framework for single-particle analysis and implemented this in the open-source program RELION (http://www2.mrc-lmb.cam.ac.uk/relion). We also use structure determination projects on challenging samples to drive our methods development. In this context, we have solved structures of ribosomes, spliceosomes, gamma-secretase and other molecules.

Keywords: Cryo-EM / RELION / ribosome / spliceosome / gamma-secretase

Subject area(s): Structural Biology & Biophysics | Proteins & Biochemistry

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