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EMBO Young Investigator

Elif Firat-Karalar

Koç University, Istanbul | Türkiye

YIP 2020

The centrosome/cilium complex and rare diseases

Our research broadly relates to understanding how cells assemble and maintain their compartments. We address this fundamental question by focusing on the mammalian centrosome/cilium complex, which functions in numerous cellular processes and is deregulated in cancer and developmental disorders. Using a multidisciplinary approach, we aim to dissect its assembly, maintenance and dynamic regulation in different contexts and diseases.

Keywords: Centrosome / primary cilium / motile cilia / centriolar satellites / ciliopathies / microtubules / proximity labeling

Subject area(s): Proteins & Biochemistry | Cell & Tissue Architecture | Cell Cycle