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EMBO Young Investigator

Felipe Cortés Ledesma

CABIMER, Sevilla | Spain

YIP 2015

DNA breaks and human disease

The research interest of the lab is to understand how DNA breaks are signalled and repaired, and how, if inefficient or aberrant, these processes can impact human health. Within this broader objective, we are specifically interested in double-strand breaks with 'blocked' DNA ends, which need to be processed before repair can take place, and therefore constitute a particular challenge for cells and organisms.

Keywords: DNA breaks / DNA damage response / DNA repair / genome instability / DNA topoisomerases

Subject area(s): Genome Stability & Dynamics | Genomic & Computational Biology | Molecular Medicine