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EMBO Member

Iva Tolic

Ruder Boskovic Institute, Zagreb | Croatia

EMBO 2018

Biophysics of the mitotic spindle

We investigate the biophysical principles underlying the mitotic spindle assembly and function. In our interdisciplinary approach, we combine cell and molecular biology, molecular genetics, biophysical tools including laser microsurgery, computer science, and theoretical physics. We are especially interested in the role of bridging fibers in spindle formation and force generation, as well as in the recently discovered chirality of the spindle.

Keywords: Mitosis / spindle / microtubules / motor proteins / kinetochore / mechanobiology / cell division / microscopy

Subject area(s): Cell Cycle | Cell & Tissue Architecture | Structural Biology & Biophysics

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