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EMBO Young Investigator

Ivan Matic

Max Planck Institute for Biology of Ageing, Cologne | Germany

YIP 2019–2023

ADP-ribosylation signalling

We use proteomics and chemical biology-based approaches to elucidate at the molecular level the role of ADP-ribosylation in biological processes. We are particularly interested in understanding how ADP-ribosylation by PARP-1, an important target for cancer therapy, regulates the DNA damage response.

Keywords: ADP-ribosylation / proteomics / chemical biology / PARP-1 / DNA repair / histones

Subject area(s): Genome Stability & Dynamics | Proteins & Biochemistry | Signal Transduction