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EMBO Young Investigator

Thomas Wollert

MPI für Biochemie, Martinsried | Germany

YIP 2015

Reconstituting autophagy in the test tube

Autophagy is a highly conserved catabolic pathway which delivers surplus or damaged cytoplasmic material to lysosomes for degradation. More than 30 proteins are involved in coordinating autophagosome biogenesis. Our goal is to understand the molecular mechanism of autophagy. We use a synthetic biology approach to recapitulate the formation of autophagosomes in the test tube.

Keywords: Autophagy / in vitro reconstitution / model membranes

Subject area(s): Membranes & Transport | Proteins & Biochemistry | Structural Biology & Biophysics