Netherlands Cancer Institute, Amsterdam | Netherlands
We develop function-based oncogenomic approaches to ask clinically relevant questions, aiming to dissect cancer-driving genetic networks for drug target and biomarker discovery. For example, we are exploring ways to enhance the activity, or avoid resistance, of currently used targeted clinical compounds. We also use unbiased screens to develop combinatorial targeted and immunotherapeutic therapies.
Keywords: Functional oncogenomics / cancer drug target and biomarker discovery / immuno-oncology / therapy resistance / senescence / metastasis / melanoma