EMBO Member
David C. Rubinsztein
EMBO 2011
Cambridge Institute for Medical Research (CIMR), Cambridge, United Kingdom
Huntington's disease, neurodegeneration and autophagy
My research aims to understand the pathogenesis of Huntington's disease and related conditions caused by aggregate-prone proteins, and towards developing rational therapeutic strategies. We have a major focus on understanding the relevance of autophagy defects as a disease mechanism and autophagy upregulation as a possible therapeutic approach, and study the basic cell biology of this important catabolic process.
Keywords
Huntington's disease / autophagy / polyglutamine disease / neurodegeneration / cell biology