EMBO Member
Jonathon Pines
EMBO 2001
Institute of Cancer Research, London, United Kingdom
Regulation of mitosis in human cells
We are studying how cells regulate mitosis to ensure that each daughter cell receives an equal and identical complement of the genome. We are focussing on the role of the mitotic kinases and the Anaphase Promoting Complex/Cyclosome (APC/C); in particular how the APC/C is controlled by the Spindle Assembly Checkpoint.
Keywords
Control of mitosis / cyclin / CDKs / live cell imaging / ubiquitin-mediated proteolysis