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EMBO Member

Tim Clausen

IMP, Vienna | Austria

EMBO 2010 | MemC 14–17

Molecular mechanisms of protein quality control

The misfolding and aggregation of protein molecules is a severe danger for cell viability. All living organisms therefore evolved a sophisticated network of molecular chaperones and proteases to reduce the amount of aberrant proteins, a process that is regulated by multiple stress response pathways. My group performs a structure-function analysis of several of these factors in order to better understand how cells deal with stress situations.

Keywords: Macromolecular machines / protein quality control / chaperone networks / regulatory proteolysis / stress response

Subject area(s): Proteins & Biochemistry | Signal Transduction | Structural Biology & Biophysics

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