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EMBO Member

A. Francis Stewart

Technische Universit├Ąt, Dresden | Germany

EMBO 2007

Epigenetic regulation of gene expression

My lab works on chromatin and the regulation of gene expression in mammalian development with emphasis on trithorax-Group action. We identified the PHD finger and the first histone 3 lysine 4 methyltransferase complex and have a current focus on the epigenome from germ cells to adult. To help unravel the epigenome, we developed a variety of methods, including ligand activated conditional mutagenesis (e.g. CreERT) and recombineering.

Keywords: Epigenetics / histone modifications / chromatin / genetic engineering / mouse models

Subject area(s): Chromatin & Transcription | Development | Genome Stability & Dynamics