Biological mechanisms of longevity
Recent progress over the last several decades has revealed that animal life span is genetically regulated and malleable. My laboratory uses the small roundworm C. elegans as a model system to unravel molecular mechanisms underlying animal longevity and age-related disease, focusing on nutrient sensing pathways, transcription factor networks, and downstream processes of metabolism and proteostasis.
Keywords
Ageing / transcriptional regulation / protein homeostasis / metabolism