Molecular mechanisms of gene transcription.
My goal is to understand the interplay between transcription factors, Pol II and chromatin coactivator complexes, and uncover fundamental molecular mechanisms of transcription and its regulation. My lab uses a multi-disciplinary approach encompassing crystallography, cryo-electron microscopy, biochemistry, biophysics and genetics to study the large macromolecular machines required for gene transcription.
Keywords
Coactivator / transcription / chromatin / structural biology / genome biology / histone modifications / epigenetics