Transcription and alternative splicing
Our lab works on the regulation of alternative pre-mRNA splicing, explaining how a single gene generates multiple proteins. We found that promoters affect alternative splicing through changes in transcriptional elongation and recruitment of splicing factors to the RNA polymerase. We also found how DNA damage and epigenetic chromatin changes modulate alternative splicing through its coupling with transcription.
Keywords
Alternative splicing / transcription / coupling / RNA polymerase II elongation / chromatin