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EMBO Member

Alexander Stark

Research Institute of Molecular Pathology (IMP), Vienna | Austria

EMBO 2015

Understanding gene regulatory DNA sequences.

The regulation of gene expression is a crucial process in all organisms. While the DNA sequence of cis-regulatory elements (enhancers) encodes the regulatory information needed to specify gene expression patterns, the requirements for enhancer activity remain unknown. We use bioinformatics and molecular biology to decipher gene regulatory sequences and study the proteins that cells employ to regulate gene expression.

Keywords: Regulatory genomics / transcriptional regulation / enhancers / CRMs / computational biology / transcription factor cofactors

Subject area(s): Chromatin & Transcription | Genomic & Computational Biology | Systems Biology