Stem cell regulation and tissue homeostasis
Our group aims to elucidate cell-intrinsic and cell-extrinsic processes controlling stem cell fate and genome stability. Ultimately, we would like to understand the control mechanisms that allow stem cells to promote tissue homeostasis in young, healthy contexts and how these become defective during aging or disease. We combine genetic approaches with genomics and imaging techniques in Drosophila to define conserved mechanisms of stem cell biology.
Keywords
Stem cells / cell fate decisions / genome instability / tissue homeostasis / aging / gap junctions / tissue mechanics / metabolism