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EMBO Associate Member

Alpha S. Yap

The University of Queensland, Brisbane | Australia

EMBO 2024

Epithelial mechanobiology and homeostasis

We study how tissue mechanics and mechanotransduction contribute to epithelial homeostasis. In particular, we are interested in understanding how cell-cell junctions serve as hubs to detect changes in force balance associated with homeostatic disturbance and elicit cellular responses to restore homeostasis. We apply experimental approaches combined with physical theory and modelling, using cellular and zebrafish models.

Keywords: Cadherin / myosin II / mechanotransduction / cell-cell junctions / actin dynamics / epithelia

Subject area(s): Signal Transduction | Membranes & Transport | Cell & Tissue Architecture