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EMBO Young Investigator

Alvaro Rada-Iglesias

Universität, Köln | Germany

YIP 2018

Transcriptional control in development and disease

The establishment of gene expression programs largely depends on distal regulatory elements known as enhancers. Furthermore, genetic or structural disruption of enhancer landscapes can lead to human disease. By functionally and mechanistically characterizing enhancers, my laboratory aims at uncovering regulatory principles orchestrating mammalian embryogenesis and elucidating the genetic and epigenetic basis of human congenital diseases.

Keywords: Enhancers / chromatin / congenital disease / development / pluripotency / differentiation / disease modelling / competence

Subject area(s): Genomic & Computational Biology | Development | Chromatin & Transcription

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