EMBO Young Investigator
Universität, Köln | Germany
The establishment of gene expression programs largely depends on distal regulatory elements known as enhancers. Furthermore, genetic or structural disruption of enhancer landscapes can lead to human disease. By functionally and mechanistically characterizing enhancers, my laboratory aims at uncovering regulatory principles orchestrating mammalian embryogenesis and elucidating the genetic and epigenetic basis of human congenital diseases.
Keywords: Enhancers / chromatin / congenital disease / development / pluripotency / differentiation / disease modelling / competence