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EMBO Member

Alwin Köhler

Max Perutz Labs, Vienna | Austria

EMBO 2021 | GinC 24–27

Nuclear envelope biology: gates, chromatin and lipids

I am interested in the nuclear envelope, the boundary that emerged at the prokaryote-eukaryote transition. The nuclear envelope combines durability with plasticity, selective traffic with mass transport, spatial enclosure with sophisticated signaling. It enables cells to protect, decode and regulate their genome. How a single intelligent boundary can achieve this multitude of integrated functions is one of the biggest puzzles in biology.

Keywords: Nuclear envelope / nuclear pore complex / chromatin / transcription-coupled mRNA export / ubiquitin signaling / nuclear lipid droplets / lipid metabolism

Subject area(s): Cellular Metabolism | Chromatin & Transcription | Membranes & Transport | RNA