Molecular bases for health and disease
We work in translational research; we focus on the molecular mechanisms by which kinases control cell behavior and, when altered, human disease. In recent years, we have concentrated on PI3-kinase, an enzyme that generates the PIP3 product, which is increased in cancer and autoimmunity. Specific topics: (i) Molecular bases and preclinical use for PI3-kinase function in cancer and inflammation. (ii) Mechanism for PI3-kinase beta action on DNA/chromatin remodeling.
Keywords
Phosphoinositide 3-kinase / signal transduction / cancer / inflammation / cell division