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EMBO Member

Ana I. Domingos

University of Oxford | United Kingdom

EMBO 2025

Neuroimmunometabolism of sympathetic circuits

Our research focuses on the interplay between neural circuits, immune cells and adipocytes. We explore the neurobiological basis of obesity, with a particular interest in the role of sympathetic neural networks. We aim to pharmacologically target these circuits to combat obesity without side effects. By uncovering novel nerve-immune-fat interactions and pioneering 'sympathofacilitator' drugs, we helped define the field of neuroimmunometabolism.

Keywords: Obesity / sympathetic neurons / adipocytes / thermogenesis / macrophages / neuroimmunity / immunometabolism / leptin

Subject area(s): Cellular Metabolism | Molecular Medicine | Neuroscience

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