Gene regulation and genome architecture
We study how 3D genome architecture regulates mammalian gene expression in stem cells, neurons and in disease. We investigate RNA polymerase II modification, Polycomb mediated repression and long-range chromatin folding, to understand gene regulation mechanisms that prime genes for future activation and modulate levels of expression.
Keywords
Genome architecture / long-range gene regulation / RNA polymerase II / Polycomb repression / stem cells / neurons