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EMBO Member

Ana Pombo

Cetemares MARE Polit├ęcnico de Leiria, Peniche | Portugal

EMBO 2018

Gene regulation and genome architecture

We study how 3D genome architecture regulates mammalian gene expression in stem cells, neurons and in disease. We investigate RNA polymerase II modification, Polycomb mediated repression and long-range chromatin folding, to understand gene regulation mechanisms that prime genes for future activation and modulate levels of expression.

Keywords: Genome architecture / long-range gene regulation / RNA polymerase II / Polycomb repression / stem cells / neurons

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Systems Biology

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