Netherlands Cancer Institute, Amsterdam | Netherlands
Our lab on one hand develops computational methods for constructing experimental and computational atomic models of proteins, developing new ideas, tools and resources for the community (e.g. PDB-REDO, AlphaFill). Concurrently, we study the structure and interactions of macromolecules involved in lysophosphatidic acid signalling and maintain a network of collaborations that focuses on the role of microtubule interactions to modulate cellular function.
Keywords: Structural biology / X-ray crystallography / tubulin detyrosination / spindle assembly checkpoint / autotaxin / AlphaFill / PDB-REDO