EMBO Member
Andor Udvardy
EMBO 1996
Biological Research Centre, Szeged, Hungary
Postsynthetic modification of proteasomal subunits
The main goal of our current research activity is the analysis of the regulation of the proteolytic activity of the 26S proteasome by postsynthetic modifications of proteasomal subunits. We identified the lysine residues of the ubiquitin-receptor subunit of the Drosophila 26S proteasome which are multiubiquitinated in vivo, and by the analysis of transgenic Drosophila lines we demonstrated the vital role of this postsynthetic modification.
Keywords
Intracellular protein degradation / 26S proteasome / regulation of the cell cycle / chromatin insulators / ubiquitylation