Maintenance of genome stability
Genomic instability is a key event in cancer and aging. We are exploring the nature and causes of genomic instability, the mechanisms of DNA repair and the consequences of failure in DNA repair with respect to cancer development. Our research emphasizes mechanistic understanding of the pathways that maintain genomic integrity, the intersection of these pathways with normal cellular physiology and cancer, as well as the application of these insights to clinical problems.
Keywords
Genome stability / DNA replication / chromatin / translocations / epigenetics