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EMBO Young Investigator

Andrea Alimonti

Oncology Institute of Southern Switzerland (IOSI), Bellinzona | Switzerland

YIP 2016

Regulation of senescence in cancer and therapy

My lab focuses on the identification of the biological mechanisms that control senescence evasion in cancer cells, acting in a cell-autonomous and non-cell-autonomous manner. We are particularly interested in how the tumour microenvironment and immune response regulate senescence in tumours upon loss of PTEN. We believe that a combination of immunotherapy and pro-senescence compounds may be beneficial for cancer therapy

Keywords: Senescence / cancer / PTEN / tumor immunology / myeloid cells

Subject area(s): Immunology | Molecular Medicine | Signal Transduction