Gurdon Institute, Cambridge | United Kingdom
EMBO 2000 | YipC 09–12
Discovering how stem cells are maintained in a multipotent state and how their progeny differentiate into distinct cellular fates is a key step in the therapeutic use of stem cells to repair tissues after damage or disease. We are investigating the systemic and local signals that regulate neural stem cell growth and proliferation and the role of glial cells in inducing stem cell exit from quiescence.
Keywords: Neural stem cell / asymmetric division / self renewal / differentiation / quiescence