My lab is interested in the mechanisms that initiate life of sexually reproducing organisms. What is the molecular basis of fertilization? How is the egg cytoplasm, and in particular the ribosome, remodeled during embryogenesis? And what is the contribution of largely neglected small proteins? We combine genetic studies in zebrafish and medaka with biochemistry, cell biology, live-cell imaging and genomics to study these fundamental questions.
Keywords: Fertilization / sperm-egg interaction / translation / ribosome / zebrafish / short ORFs / early embryogenesis