EMBO Member
Andrea Pauli
EMBO 2021
Former EMBO Young Investigator (2019)
Research Institute of Molecular Pathology (IMP), Vienna, Austria
Molecular control of the egg-to-embryo transition
My lab is interested in the mechanisms that initiate life of sexually reproducing organisms. What is the molecular basis of fertilization? How is the egg cytoplasm, and in particular the ribosome, remodeled during embryogenesis? And what is the contribution of largely neglected small proteins? We combine genetic studies in zebrafish and medaka with biochemistry, cell biology, live-cell imaging and genomics to study these fundamental questions.
Keywords
Fertilization / sperm-egg interaction / translation / ribosome / zebrafish / short ORFs / early embryogenesis