University, Zurich | Switzerland
We study the creation of new proteins and protein variants. The purpose of this work is to use such engineered proteins to enable research and applications which have been very difficult or even impossible so far. Examples of our endeavors are the creation of new engineered binding proteins to inhibit other proteins or to kill tumor cells, or the stabilization of proteins so that they can be studied structurally and biophysically.
Keywords: Protein engineering / recombinant antibodies / directed evolution / GPCRs / novel scaffolds