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EMBO Member

Andreas Plückthun

University, Zurich | Switzerland

EMBO 1992

Protein Engineering

We study the creation of new proteins and variants. The purpose of this work is to use such engineered proteins to enable novel research and biomedical applications. Examples of our endeavors are new binding proteins (DARPins, Armadillo Repeat proteins), highly stabilized GPCRs, and engineered virus-like particles for targeted gene delivery. Our work is very interdisciplinary, from structural and biophysical studies to in vivo applications.

Keywords: Protein engineering / recombinant antibodies / directed evolution / GPCRs / DARPins / Armadillo Repeat Proteins / protein design

Subject area(s): Molecular Medicine | Proteins & Biochemistry | Structural Biology & Biophysics