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EMBO Member

Andreas Radbruch

Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin | Germany

EMBO 2010

Immunological memory in immunity and immunopathology

My lab aims at a systemic understanding of immunological memory and its role in protective immunity and immunopathology, in particular memory plasma cells and memory T helper lymphocytes. We have analysed the regulation of antibody switch recombination, and the epigenetic and transcriptional imprinting of memory cells. We have developed the concept of a resting protective immunological memory organized by stromal cells, and of a pathogenic memory driving chronic inflammation.

Keywords: Immunological memory / lymphocytes / plasma cells / epigenetics / flow cytometry & cell sorting

Subject area(s): Immunology | Molecular Medicine