EMBO Member

Andrew J. Newman

MRC LMB, Cambridge | United Kingdom

EMBO 1995

Spliceosome structure and function

In collaboration with Kiyoshi Nagai, my current research uses biochemical, genetic and structural methods to understand the structure and functions of the U5 snRNP protein Prp8: the largest and most conserved spliceosomal protein. Prp8 forms the active site cavity of the spliceosome and interacts extensively with crucial sequences in the spliceosome's catalytic RNA core.

Keywords: Splicing of mRNA precursors / structure & function of spliceosomes / Prp8 protein / U5 snRNP

Subject area(s): RNA