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EMBO Member

Andrew P. Carter

MRC LMB, Cambridge | United Kingdom

EMBO 2016 | InstgC 22–25

Structural biology of the motor protein dynein

My group works on the dynein family of microtubule motor proteins. Dyneins power the beating of cilia and flagella, transport a large variety of intracellular cargos and play important roles in mitosis. They are hijacked by viruses during infection and mutations in them are linked to diseases such as neurodegeneration. We use structural biology and single molecule techniques to study the function of the large multiprotein dynein complex.

Keywords: Dynein / dynactin / microtubule transport / motor proteins / structural biology

Subject area(s): Membranes & Transport | Proteins & Biochemistry | Structural Biology & Biophysics