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EMBO Member

Angel R. Nebreda

Institut de Recerca Biomèdica (IRB), Barcelona | Spain

EMBO 2003 | YipC 08–11

Signal integration and cell cycle regulation

I am interested in molecular mechanisms of tumorigenesis, especially regarding how signalling pathways regulate cell viability, proliferation and invasion, using a combination of biochemical approaches and studies in human cancer cell lines. My group also uses genetically modified mouse models that allow the inactivation of particular proteins in a regulated and tissue-specific manner to investigate tumor formation in vivo.

Keywords: MAP kinases / signal transduction / cyclin-dependent kinases / mouse models / oocyte meiotic maturation / cell proliferation, differentiation & survival

Subject area(s): Cell Cycle | Differentiation & Death | Signal Transduction