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EMBO Member

Angel R. Nebreda

Institut de Recerca Biomèdica (IRB), Barcelona | Spain

EMBO 2003 | YipC 08–11

Stress kinase signaling

We investigate mechanisms that allow cells to interpret stress signals mediated by the p38 MAPK pathway, addressing physiological functions and its role in tumorigenesis. Current interests include cancer cell homeostasis and chemoresistance, the cross talk with stromal cells, and targeted therapies. We use a combination of biochemical approaches, studies with cell lines and primary cell cultures, and in vivo experiments with mouse models.

Keywords: MAP kinase / signaling network / stress response / cancer cell homeostasis / tumor microenvironment / mouse model / chemotherapy resistance / targeted therapy

Subject area(s): Cell Cycle | Differentiation & Death | Molecular Medicine | Signal Transduction