Institut de Recerca Biomèdica (IRB), Barcelona | Spain
EMBO 2003 | YipC 08–11
We investigate mechanisms that allow cells to interpret stress signals mediated by the p38 MAPK pathway, addressing physiological functions and its role in tumorigenesis. Current interests include cancer cell homeostasis and chemoresistance, the cross talk with stromal cells, and targeted therapies. We use a combination of biochemical approaches, studies with cell lines and primary cell cultures, and in vivo experiments with mouse models.
Keywords: MAP kinase / signaling network / stress response / cancer cell homeostasis / tumor microenvironment / mouse model / chemotherapy resistance / targeted therapy
Subject area(s): Signal Transduction | Molecular Medicine | Differentiation & Death | Cell Cycle