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EMBO Member

Anne Grapin-Botton

MPI für molekulare Zellbiologie und Genetik, Dresden | Germany

EMBO 2023

Self-organization of cells into organ communities

Our group investigates the impact of the cellular and organ architecture on the cells' fate choices and how single cells act in a community to generate an organ. To do so, we use mouse genetics and live imaging in 3D, and we developed 3D in-vitro 'organoid' culture systems modelling mouse and human development. These systems also enable us to gain insight into human syndromes impairing pancreas development.

Keywords: Developmental biology / stem cells / pancreas / organoids / endocrine / diabetes / differentiation / epithelial tubes

Subject area(s): Cell & Tissue Architecture | Development | Differentiation & Death | Molecular Medicine