Francis Crick Institute, London | United Kingdom
We study the mechanisms of induction and regulation of the immunosuppressive cytokine IL-10 in macrophages, dendritic cells and T cells to uncover mechanisms for its production and function in infections such as chronic MTb and a broad spectrum of infectious or inflammatory diseases. Leading on from our findings in human TB, we will also dissect the role of Type I IFNs and Type I IFN-inducible genes in TB pathogenesis.
Keywords: Cytokines / immune regulation / pathogens / PAMPs / tuberculosis / mycobacteria
Subject area(s): Immunology | Microbiology, Virology & Pathogens | Systems Biology