University, Bristol | United Kingdom
EMBO 2002 | CouC 05–09 | TemC 08–11
My laboratory studies how mammalian cells move in response to extracellular cues, focusing on signalling by Rho family GTPases and the cytoskeleton. We investigate how cell-cell and cell-extracellular matrix interactions are modulated during epithelial cell migration, and how leukocytes polarise and migrate in response to adhesion and chemical stimuli. We also study how leukocytes and cancer cells attach to and cross endothelial cells.
Keywords: Signal transduction / Rho GTPases / cytoskeleton / cell migration / metastasis / endothelial cells / mechanotransduction