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Biology of the synapse: from molecule to function

Studying normal and pathological synaptic biology, my objectives are: 1) to determine the relationship between the synapse microstructure, molecular dynamics, and molecular interactions; 2) to characterize the molecular mechanisms contributing to the physiological adaptation of inhibition to excitation; 3) to understand how non-neuronal glial cells modulate inhibitory receptor diffusion-trapping and ultimately impact on neuronal excitability.