Mechanistic insights into ion-coupled transport
My laboratory is involved in understanding the mechanisms and pharmacology of transport processes across eukaryotic and prokaryotic cell membranes. We focus on exploring the architecture of neurotransmitter transporters and multi-drug efflux transporters to devise strategies to block their activity for therapeutic outcomes. This allows us to study the roles of transporters in disorders like chronic pain, epilepsy and multi-drug resistance.
Keywords
Neurotransmitter transporters / multi-drug efflux / ion-coupled transport / camelid antibodies / neuropharmacology